diff --git a/arch/posix/CMakeLists.txt b/arch/posix/CMakeLists.txt
index bc06cecac27..74a0c9e2617 100644
--- a/arch/posix/CMakeLists.txt
+++ b/arch/posix/CMakeLists.txt
@@ -99,11 +99,13 @@ elseif (CONFIG_NATIVE_LIBRARY)
     get_filename_component(COMPILER_OWN_INCLUDE_PATH "${_OUTPUT}" DIRECTORY)
 
     # Do not use the C library from this compiler/host,
-    # but still use the basic compiler headers
+    # but still use the basic compiler headers,
+    # remove all operating system specific predefined macros,
     # no_builtin to avoid the compiler using builtin replacements for std library functions
     zephyr_compile_options(
       -nostdinc
       -isystem ${COMPILER_OWN_INCLUDE_PATH}
+      "SHELL:-include ${ZEPHYR_BASE}/arch/posix/include/undef_system_defines.h"
       $<TARGET_PROPERTY:compiler,freestanding>
       $<TARGET_PROPERTY:compiler,no_builtin>
     )
diff --git a/arch/posix/include/undef_system_defines.h b/arch/posix/include/undef_system_defines.h
new file mode 100644
index 00000000000..d7384e403a6
--- /dev/null
+++ b/arch/posix/include/undef_system_defines.h
@@ -0,0 +1,20 @@
+/*
+ * Copyright (c) 2024 Google LLC
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+/*
+ * Undefine all system-specific macros defined internally, by the compiler.
+ * Run 'gcc -dM -E - < /dev/null | sort' to get full list of internally
+ * defined macros.
+ */
+
+#undef __gnu_linux__
+#undef __linux
+#undef __linux__
+#undef linux
+
+#undef __unix
+#undef __unix__
+#undef unix