diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 6aabdc625..e01bd482b 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -52,6 +52,7 @@ jobs:
             args: >
               -DPYBIND11_FINDPYTHON=OFF
               -DCMAKE_CXX_FLAGS="-D_=1"
+              -DPYBIND11_NUMPY_1_ONLY=ON
             exercise_D_: 1
           - runs-on: windows-2019
             python: '3.8'
@@ -65,6 +66,7 @@ jobs:
             python: '3.9'
             args: >
               -DCMAKE_MSVC_RUNTIME_LIBRARY=MultiThreaded
+              -DPYBIND11_NUMPY_1_ONLY=ON
           - runs-on: windows-2022
             python: '3.10'
             args: >
@@ -149,14 +151,12 @@ jobs:
 
     # First build - C++11 mode and inplace
     # More-or-less randomly adding -DPYBIND11_SIMPLE_GIL_MANAGEMENT=ON here
-    # (same for PYBIND11_NUMPY_1_ONLY, but requires a NumPy 1.x at runtime).
     - name: Configure C++11 ${{ matrix.args }}
       run: >
         cmake -S . -B .
         -DPYBIND11_WERROR=ON
         -DPYBIND11_DISABLE_HANDLE_TYPE_NAME_DEFAULT_IMPLEMENTATION=ON
         -DPYBIND11_SIMPLE_GIL_MANAGEMENT=ON
-        -DPYBIND11_NUMPY_1_ONLY=ON
         -DPYBIND11_PYTEST_ARGS=-v
         -DDOWNLOAD_CATCH=ON
         -DDOWNLOAD_EIGEN=ON
@@ -180,13 +180,11 @@ jobs:
 
     # Second build - C++17 mode and in a build directory
     # More-or-less randomly adding -DPYBIND11_SIMPLE_GIL_MANAGEMENT=OFF here.
-    # (same for PYBIND11_NUMPY_1_ONLY, but requires a NumPy 1.x at runtime).
     - name: Configure C++17
       run: >
         cmake -S . -B build2
         -DPYBIND11_WERROR=ON
         -DPYBIND11_SIMPLE_GIL_MANAGEMENT=OFF
-        -DPYBIND11_NUMPY_1_ONLY=ON
         -DPYBIND11_PYTEST_ARGS=-v
         -DDOWNLOAD_CATCH=ON
         -DDOWNLOAD_EIGEN=ON
diff --git a/noxfile.py b/noxfile.py
index e9a2fa8fe..773687fb0 100644
--- a/noxfile.py
+++ b/noxfile.py
@@ -1,11 +1,16 @@
+#!/usr/bin/env -S uv run
+
+# /// script
+# dependencies = ["nox>=2025.2.9"]
+# ///
+
 from __future__ import annotations
 
 import argparse
 
 import nox
 
-nox.needs_version = ">=2024.3.2"
-nox.options.sessions = ["lint", "tests", "tests_packaging"]
+nox.needs_version = ">=2025.2.9"
 nox.options.default_venv_backend = "uv|virtualenv"
 
 
@@ -49,7 +54,7 @@ def tests_packaging(session: nox.Session) -> None:
     session.run("pytest", "tests/extra_python_package", *session.posargs)
 
 
-@nox.session(reuse_venv=True)
+@nox.session(reuse_venv=True, default=False)
 def docs(session: nox.Session) -> None:
     """
     Build the docs. Pass --non-interactive to avoid serving.
@@ -83,16 +88,15 @@ def docs(session: nox.Session) -> None:
         session.run("sphinx-build", "--keep-going", *shared_args)
 
 
-@nox.session(reuse_venv=True)
+@nox.session(reuse_venv=True, default=False)
 def make_changelog(session: nox.Session) -> None:
     """
     Inspect the closed issues and make entries for a changelog.
     """
-    session.install("ghapi", "rich")
-    session.run("python", "tools/make_changelog.py")
+    session.install_and_run_script("tools/make_changelog.py")
 
 
-@nox.session(reuse_venv=True)
+@nox.session(reuse_venv=True, default=False)
 def build(session: nox.Session) -> None:
     """
     Build SDists and wheels.
diff --git a/tests/requirements.txt b/tests/requirements.txt
index 688ff6fe8..0f6682cab 100644
--- a/tests/requirements.txt
+++ b/tests/requirements.txt
@@ -1,13 +1,16 @@
 --only-binary=:all:
-build~=1.0; python_version>="3.8"
+build>=1
 numpy~=1.23.0; python_version=="3.8" and platform_python_implementation=="PyPy"
-numpy~=1.25.0; python_version=="3.9" and platform_python_implementation=='PyPy'
+numpy~=1.25.0; python_version=="3.9" and platform_python_implementation=="PyPy"
+numpy~=2.2.0; python_version=="3.10" and platform_python_implementation=="PyPy"
 numpy~=1.26.0; platform_python_implementation=="GraalVM" and sys_platform=="linux"
-numpy~=1.21.5; platform_python_implementation!="PyPy" and platform_python_implementation!="GraalVM" and python_version>="3.8" and python_version<"3.10"
-numpy~=1.22.2; platform_python_implementation!="PyPy" and platform_python_implementation!="GraalVM" and python_version=="3.10"
-numpy~=1.26.0; platform_python_implementation!="PyPy" and platform_python_implementation!="GraalVM" and python_version>="3.11" and python_version<"3.13"
-pytest~=7.0
+numpy~=1.21.5; platform_python_implementation=="CPython" and python_version>="3.8" and python_version<"3.10"
+numpy~=1.22.2; platform_python_implementation=="CPython" and python_version=="3.10"
+numpy~=1.26.0; platform_python_implementation=="CPython" and python_version>="3.11" and python_version<"3.13"
+numpy~=2.2.0; platform_python_implementation=="CPython" and python_version=="3.13"
+pytest>=7
 pytest-timeout
-scipy~=1.5.4; platform_python_implementation!="PyPy" and platform_python_implementation!="GraalVM" and python_version<"3.10"
-scipy~=1.8.0; platform_python_implementation!="PyPy" and platform_python_implementation!="GraalVM" and python_version=="3.10" and sys_platform!='win32'
-scipy~=1.11.1; platform_python_implementation!="PyPy" and platform_python_implementation!="GraalVM" and python_version>="3.11" and python_version<"3.13" and sys_platform!='win32'
+scipy~=1.5.4; platform_python_implementation=="CPython" and python_version<"3.10"
+scipy~=1.8.0; platform_python_implementation=="CPython" and python_version=="3.10" and sys_platform!="win32"
+scipy~=1.11.1; platform_python_implementation=="CPython" and python_version>="3.11" and python_version<"3.13" and sys_platform!="win32"
+scipy~=1.15.2; platform_python_implementation=="CPython" and python_version=="3.13" and sys_platform!="win32"
diff --git a/tools/make_changelog.py b/tools/make_changelog.py
index b499d06ba..147ce1a97 100755
--- a/tools/make_changelog.py
+++ b/tools/make_changelog.py
@@ -1,4 +1,9 @@
-#!/usr/bin/env python3
+#!/usr/bin/env -S uv run
+
+# /// script
+# dependencies = ["ghapi", "rich"]
+# ///
+
 from __future__ import annotations
 
 import re